Assessment of vitamin A status in patients with systemic inflammation using retinol binding protein/prealbumin ratio. Permjeet Ghandi for MSc in Biomedical Sciences. Status: on-going.
Analysis of copper oxidase and its clinical role. David Preiss, SpR in Clinical Biochemistry, Glasgow Royal Infirmary. Status: Writing up for FRCPath dissertation.
Audit of zinc-induced copper deficiency. Fiona Stefanowicz. Status: patient review.
Correlation of trace element concentrations in human liver, muscle and blood. Jennifer Logue SpR. Status: study completed, MD being written up.
Method validation, establishing population reference interval and assessing clinical utility of measuring ADMA in various patient groups. Scott Blackwell, SpR. Status: on-going.
Method development for the simultaneous measurement of vitamins B2 and B6 in red blood cells. Kirsty Fyffe, Summer Student. Status: analysis completed, data being analysed.
Establishing reference range for glutathione peroxidase. Fiona Stefanowicz. Status: Completed.
HPLC analysis of asymmetric dimethylarginine (ADMA) and related arginine metabolites in human plasma using a novel non-endogenous internal standard. Scott Blackwell, SpR. Status: Completed submitted for FRCPath.
Vitamin antioxidants, lipid peroxidation, tumour stage, the systemic inflammatory response and survival in patients with colorectal cancer. Elaine Leung. Status: Completed; writing up for publication.
Lipid peroxidation in patients with critical illness. Linda White, BSc. Clinical Medicine project. Status: Study completed, paper submitted.
Measurement of cellular oxidative stress following elective orthopaedic surgery. David Reid. Status: on-going.
Assessment of vitamin D status in patients with critical illness. David Reid. Dept Surgery. Status: on-going.
Exercise / oxidative stress study in breast cancer. Rani Jassal. Status: completed; report submitted for BSc project.
Collaborative Studies
Endogenous antioxidant capacity and oxidative stress after thoracic surgery. Collaborator: Ben Shelley, Clinical research fellow. Dept Anaesthesia. Status: samples being collected.
Establishing plasma copper reference ranges using National Health and Nutrition Examination Survey data. Collaborator: Professor Chris Robertson, Professor of Public Health Epidemiology, University of Strathclyde. Status: analysis complete.
Longitudinal observation study of vitamin E concentrations in critically ill patients. Collaborator: Dimitra Leivaditi, MSc Human Nutrition, Glasgow University. Study completed; MSc written up; paper published.
Audit of micronutrient status in patients on long-term home parenteral nutrition. Collaborator: Nicki Haslam, Department of Surgery, Glasgow Royal Infirmary, Home Parenteral Nutrition Management Clinical Network, Dundee. Status: writing up.
The potential of trace elements in sputum in assessing inflammation in the respiratory tract.. Collaborator: Robert Gray Respiratory Medicine Unit, Western General Hospital, Edinburgh. Status: study completed, written up and published.
Essential and toxic trace element concentrations in tissues from deceased long-term total parenteral nutrition patients. Collaborator: Lyn Howard, Department of Medicine, Albany Medical College, New York. Status: Sample analysis.
Effect of mercury poisoning on long-term health in dentists. Collaborators: Ewan MacDonald, Occupational Health, Glasgow University, Margie Taylor, Chief Dental Officer. Design stage.
UK audit of zinc supplementation in Intensive Care Units. Collaborator: Pamela Dean, Malcolm Simm, John Kinsella, ICU, Glasgow Royal Infirmary. Status: data being analysed.
Vitamin A supplementation and retinal function and conjunctival health in very low birth weight infants. Collaborator: Dr H Mactier, Yorkhill Hospital. Status: patient recruitment
Measurement of cellular oxidative stress following elective orthopaedic surgery. Collaborator: David Reid, Dept of Anaesthesia. Status: sample analysis.
Development and evaluation of a clinical screening instrument to aid earlier identification and treatment of Alcohol Related Thiamine deficiency. Collaborator: Helen Bennewith, Glasgow Addiction Services. Status: patient recruitment.
External quality assurance scheme for liver copper and iron. Andrew Duncan. Status: first year of two year pilot completed.
Development of paediatric reference ranges for trace elements and vitamins. Collaborator: Kostas Gerasimidis, Department of Human Nutrition, Yorkhill Hospital. Status: In design stage.
Investigation into the distribution of thiopurine S-methyltransferase activity in the population of Glasgow. Collaborator: David Paisley, Soutnern General Hospital. Status: MSC project completed. Assay introduced as new service.
Vitamin antioxidants, lipid peroxidation, tumour stage, the systemic inflammatory response and survival in patients with colorectal cancer. Collaborator: Campbell Roxburgh, Dept Surgery. Status: on-going.
Assessing micronutrient status in patients with critical illness. Collaborator: Aikaterini Vasilaki, Dept Surgery. Status: thesis written.
The relationship between biochemical markers of the systemic inflammatory response and survival: A population-based study. Collaborator: Michael Proctor. Status: on-going.
Method development and evaluation of sarcosine (methyl glycine) as a biomarker in prostate cancer. Collaborator: Sarah Williamson, Nuffield Foundation. Status: completed.
Vitamin antioxidants, lipid peroxidation, tumour stage, the systemic inflammatory response and survival in patients with pancreatic cancer. Collaborator: Vishnu Chandraban. Status: samples being collected.
